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KMID : 0545120210310060875
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Journal of Microbiology and Biotechnology
2021 Volume.31 No. 6 p.875 ~ p.881
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Mitochondrial Targeting Domain Homologs Induce Necrotic Cell Death Via Mitochondrial and Endoplasmic Reticulum Disruption
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Park Jung-Hee
Han Ji-Hye
Myung Seung-Hyun
Chung Hea-Jong
Park Jae-Il
Cho Ju-Yeon
Kim Tae-Hyoung
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Abstract
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The mitochondrial targeting domain (MTD) of Noxa contributes to its mitochondrial localization and to apoptosis induction. As a peptide, MTD fused with octa-arginine (R8), a CPP, induces necrosis related to intracellular calcium influx and destruction of mitochondria and endoplasmic reticulum. We searched for homologs of MTD, and compared their cell killing capability when fused with R8. Three of the seven peptides triggered cell death with similar mechanisms. The comparative analysis of peptide sequences showed that four amino acid sites of MTD are critical in regulating necrosis, suggesting the potential to generate artificial, adjustable cytotoxic peptides, which could be effective medicines for many diseases. Thus, homologs functionality could hint to the functions of their belonging proteins.
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KEYWORD
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MTD, MTD homologs, necrotic cell death, mitochondria
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